Trihomoniaz.ru " Lakarstvennye drugs
5-nitroimidazole - antimicrobial drugs for the treatment of bacterial and protozoal infections
EN Padeyskaya. Alliance Clinical Chemotherapeutists and microbiologists, Moscow Consilium-Midicum, vol.6, № 1 (2004)
Nimorazol (Nimorazole)
The active substance "Nimorazol"
List of names of drugs with active ingredient "Nimorazol"
Metronidazole (Metronidazole)
Active substance "Metronidazole"
List of names of drugs with the active ingredient "Metronidazole"
Tinidazole (Tinidazole)
Current substance "Tinidazole '
List of names of drugs with active ingredient "Tinidazole"
Ornidazole (Ornidazole)
Active substance "ornidazole"
List of names of drugs with active ingredient "ornidazole"
Seknidazol (Secnidazole)
Active substance "Seknidazol"
List of names of drugs with the active substance "Seknidazol"
Ternidazol (Ternidazole)
Active substance "Ternidazol" - a drug for local use
List of names of drugs with the active ingredient "Ternidazol"
Trihomoniaz.ru ' Lakarstvennye drugs 'Tinidazole (Tinidazole)
Tinidazole (Tinidazole)
Article Categories: Lakarstvennye drugs, 5-nitroimidazole, Tinidazole
Russian name: Tinidazole
Latin name: Tinidazole
Chemical name: 1 - [2 - (Etilsulfonil) ethyl]-2-methyl-5-nitro-1H-imidazole
Gross-formula: C8H13N3O4S
Code CAS: 19387-91-8
Pharmacology
Mode of action - protivoprotozoynoe, protivomikrobnoe.Blagodarya highly lipophilic, easily penetrates the trichomonads and anaerobic microorganisms, which restored nitroreduktazoy and destroys bacterial DNA. If ingestion is rapidly absorbed, the percentage of absorption - about 90%. Accumulates in blood, Cmax achieved in 2 hours connection with plasma proteins - 10%. It is easy to penetrate various tissues and body fluids, passes through the BBB. Biotransformation, the major metabolites are pharmacologically active hydroxylated substances (inhibit growth of anaerobic microorganisms, and may exacerbate the effects of tinidazole). Slow extraction (including metabolites) kidneys (intensive reabsorption in the renal tubules). T1 / 2 in adults is 10-14 h.
Has protivoprotozoynoy active against Trichomonas vaginalis, Entamoeba histolytica, as well as about 90% of various types of anaerobic microorganisms (Bact. fragilis, the majority of strains fuzobaktery, peptostreptokokkov, various clostridia). Bact. fragilis makes tinidazole in metabolites, depressants also a number of aerobes, in vitro is not sensitive to the nitroimidazole.
Application
Acute and chronic trichomoniasis, amoebiasis and giardiasis, cutaneous leishmaniasis, anaerobic and mixed infections of different localization (lung abscess, brain, infective endocarditis, etc.).
Contraindications
Hypersensitivity, blood diseases, diseases of the central nervous system in the active phase, pregnancy (I term).
Restrictions on the use
Breastfeeding (should stop breastfeeding), age 12 years (especially in case of violation of the excretory function of kidneys).
Side effects
Dyspeptic disorders (loss of appetite, nausea, sometimes vomiting, diarrhea), transient leucopenia, with prolonged use - dizziness, ataxia, dysarthria, and sometimes convulsions, paresthesia, and in isolated cases - an allergic reaction.
Interaction
Compatible with sulphonamides and antibiotics (aminoglycosides, erythromycin, rifampicin, cephalosporins); not advisable to appoint a Ethionamide. Phenobarbital accelerates the inactivation in the liver. Enhances the effect of proximity anticoagulants (to reduce the risk of bleeding is recommended to reduce their dose to 50%).
Dosing and Administration
Inside, with trichomoniasis and giardiasis in a single dose - 2 grams during or after meals, with amoebiasis adults - 2 g 1 time per day for 2-3 days. Children - at 0,05-0,06 g / kg 1 time a day for 3 days, with amoebic liver abscess adults - 4,5-10 g for the full course, children - to 0,05 g / kg for 5 days.
Cautions
It was dark urine. During treatment, prohibited the use of alcoholic beverages in order to avoid the development of intestinal colic, nausea, vomiting.
Trading names of drugs with active ingredient "Tinidazole"
Vero Tinidazole
Tiniba
Tinidazole
Tinidazole Acre ®
Fazizhin
Other materials on the active substance "Tinidazole"
Seknidazol (Secnidazole)
Article Categories: Lakarstvennye drugs, 5-nitroimidazole, Seknidazol
Russian title: Seknidazol
Latin name: Secnidazole
Chemical Name: alpha ,2-dimethyl-5-nitro-1H-imidazole-1-ethanol
The empirical formula: C7H11N3O3
Code CAS: 3366-95-8
Pharmacology
Mode of action - antibacterial, protivoprotozoynoe. Has bactericidal activity against most anaerobic bacteria and many protozoa. Interacts with the DNA of microbial cells, violates its helical structure, is the disruption of filaments and inhibits the synthesis of nucleic acids, inhibits the processes of reduction (very typical for anaerobes).
Once inside a well (80%) absorbed. Cmax is created after 4 hours Biotransformiruetsya in the liver. T1 / 2 - about 20 hours passing through the placental barrier and is secreted in breast milk. We derive a slow, mainly in the urine.
Application
Urethritis and vaginitis caused by Trichomonas vaginalis; amebiasis intestinal and liver, giardiasis.
Contraindications
Hypersensitivity (including to other imidazole derivative), pathological changes of the blood (including history), organic diseases of the central nervous system (active stage), pregnancy, breast-feeding.
Application of pregnancy and breastfeeding
Contraindicated during pregnancy. At the time of treatment should stop breastfeeding.
Side effects
Digestive disorders, nausea, pain in the stomach, metallic taste in the mouth, glossitis, stomatitis, leukopenia, rash, rarely - dizziness, poor coordination of movements, ataxia, paraesthesia, polyneuropathy.
Interaction
Increases the anticoagulant effect of coumarin derivatives and indandiona. In combination with disulfiram causes paranoid reaction and psychosis, alcohol - symptoms disulfiramopodobnoy reactions (abdominal cramps, nausea, vomiting, headache, rush of blood to the face).
Dosing and Administration
Inside, before eating, drinking a small amount of water or mixed with semisolid food. Urethritis and Vaginitis: 2 g once. Amoebiasis intestinal giardiasis: a single dose, adults - 2 g, children - 30 mg / kg. Amoebiasis of the liver: in 5 days, adults - 1.5 g / day, children - 30 mg / kg / day (single dose or in divided doses).
Cautions
When hepatic amoebiasis treatment should be combined with the removal of pus from the abscess.
Trading names of drugs with active ingredient Seknidazol
Seknidazol
