Nimorazol (Nimorazole)
Russian title: Nimorazol
Latin name: Nimorazole
Chemical name: 4 - [2 - (5-Nitro-1H-imidazol-1-yl) ethyl] morpholine
Gross-formula: C9H14N4O3
Code CAS: 6506-37-2
Pharmacological action
Protivoprotozoynoe means derivative 5-nitroimidazole. Mechanism of action related to DNA damage sensitive organisms.
Nimorazol active against Trichomonas vaginalis, Giardia lamblia, Entamoeba histolytica, anaerobic gram of bacteria, including Bacteroides fragilis.
Statement
Trichomoniasis, vaginitis caused by Gardnerella vaginalis, giardiasis, amebiasis, acute ulcerative necrotizing gingivitis.
Once inside quickly and completely absorbed. Receiving 1500 mg (500 mg every 12 h) creates a 3 h the concentration in the blood, exceeding the minimum trihomonatsidnuyu (0,3-3 mg / ml) more than 5 times (16 mg / ml) after 25 hours - more than 9 times (28 mg / ml) and 12 h after the last intake - more than 2.5 times (7.5 mg / ml). Well into the different organs and tissues, biological fluids (including vaginal secretions and urine). Biotransformation in the liver with the formation of active metabolites. Excreted by the kidneys mainly as unchanged, and in the form of active metabolites.
Contraindications
Hypersensitivity diseases, central nervous system and peripheral nerves, disruption of the liver and kidneys, pregnancy, lactation, children's age (no information on the use of the drug in children).
Application of pregnancy and breastfeeding
Contraindicated during pregnancy. At the time of treatment should stop breastfeeding.
Side effects
Dizziness, drowsiness, polyneuropathy, paresthesia, worsening mental illness, dyspepsia (nausea, vomiting, heartburn, pain in the epigastric region), abnormal liver function, allergic reactions (skin rash, itching).
Interaction
The likelihood of adverse reactions increases alcohol.
Dosing and Administration
They carry out simultaneous treatment of sexual partners. Dose for adults - 500 mg 2 times a day for 6 days or 2 g of 1 times a day for 1-2 days. After completing the course in the bacteriological recovery is possible to preserve clinical symptoms within a few days.
Precautionary measures
During the treatment is not recommended to drink alcoholic beverages.
Trading names of drugs with active ingredient Nimorazol
Naksodzhin
Table. 500 mg vials. dark. glass. 6 Pace. cardboard. 1; № 011956/01, 18.11.2005 from Pharmacia Italia (Italy); post.: Pfizer (USA); code EAN: 4601955000204
